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  1. History. Born in Nancy, Francis was the eldest son of Antoine, Duke of Lorraine and Renée de Bourbon, daughter of Gilbert de Bourbon, Count of Montpensier.He was briefly engaged in the mid-1530s to Anne of Cleves, who in 1540 would become the fourth wife of King Henry VIII of England.

  2. In reaction to the dominating power at court of the ultra-Catholic Guises, La Renaudie, a Protestant gentleman of Périgord, perhaps at the distanced instigation of Louis of Bourbon, Prince of Condé, organized a plot, the conspiracy of Amboise, to seize the person of the Duke of Guise and his brother Charles, the Cardinal of Lorraine.