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10 de may. de 2024 · William G. Kaelin, Jr. (born 1957, New York City, New York) is an American scientist known for his studies of tumour suppressor genes and proteins and for his role in identifying the molecular mechanisms that allow cells to sense and adapt to changes in oxygen levels.
- Kara Rogers
25 de abr. de 2024 · A new paper by Dana-Farber Cancer Institute scientists lays the foundation for targeted therapies to inhibit activation of nuclear factor kappa B (NF-κB), a transcription factor that plays a role in various autoimmune and inflammatory diseases and cancers.
2 de may. de 2024 · Specialty. Medical Sciences. Elected. 2020. The von Hippel-Lindau hereditary cancer syndrome led Kaelin to speculate that the VHL gene is critical for oxygen sensing and the finding that the VHL protein (pVHL) forms an ubiquitin ligase-like complex that suppresses hypoxia-inducible mRNAs.
9 de may. de 2024 · Dr. William G. Kaelin, Jr., of the Dana-Farber Cancer Institute in Boston, discusses some of the latest developments in the use of targeted therapies for renal cell carcinoma.
- Cottage Hospital, Woodsville, New Hampshire
25 de abr. de 2024 · Electronic address: william_kaelin@dfci.harvard.edu. PMID: 38670073. DOI: 10.1016/j.cell.2024.03.022. Abstract. Nuclear factor κB (NF-κB) plays roles in various diseases. Many inflammatory signals, such as circulating lipopolysaccharides (LPSs), activate NF-κB via specific receptors.
25 de abr. de 2024 · William G. Kaelin Jr. Open Access Innovative approaches identify druggable glycosylation processes that regulate TLR4-mediated activation of the pro-inflammatory transcription factor NF-κB.
25 de abr. de 2024 · Read the latest articles of Cell at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature.
