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Hace 2 días · Abstract: Metformin, an antidiabetic agent, has been a cornerstone in the management of type 2 diabetes since its approval by the. U.S. Food and Drug Administration (FDA) in 1994. Available in imm ...
Hace 1 día · Previous use of other antidiabetic drugs. Hepatic failure defined as: Aspartate aminotransferase (AST), Alanine transaminase (ALT) or Bilirubin > 3X upper limits level compared to reference levels.
Hace 2 días · Theoretically, antidiabetic drugs designed to ameliorate insulin resistance within the brain hold promise in preventing Alzheimer's disease or dementia [18, 31]. In a study involving 17,200 new users of metformin, a lower risk of dementia was reported in a subset of younger veterans exhibiting HbA1C values ≥ 7%, those with good renal function, and individuals of white ethnicity [ 13 ].
Hace 2 días · Participants not receiving any antidiabetic drugs. Antidiabetic drugs (biguanides, sulfonylureas, glinides, alpha-glucosidase inhibitors, thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, insulin preparations) other than SGLT2 inhibitors will be appropriately selected and administered by the investigator, taking into consideration the participants’ disease condition.
Hace 4 días · Objective To compare the effectiveness of three commonly prescribed oral antidiabetic drugs added to metformin for people with type 2 diabetes mellitus requiring second line treatment in routine clinical practice. Design Cohort study emulating a comparative effectiveness trial (target trial). Setting Linked primary care, hospital, and death data in England, 2015-21. Participants 75 739 adults ...
Hace 2 días · AMA Style. Plowman TJ, Christensen H, Aiges M, Fernandez E, Shah MH, Ramana KV. Anti-Inflammatory Potential of the Anti-Diabetic Drug Metformin in the Prevention of Inflammatory Complications and Infectious Diseases Including COVID-19: A Narrative Review.
Hace 2 días · Aim To investigate the impact of the COVID-19-pandemic on antidiabetic drug initiation Methods Using Swedish national health registers, an interrupted time series study for all first-time dispensed antidiabetic drugs was performed. A minimum 14-month washout period was used. We calculated monthly cumulative incidence of antidiabetic drug initiations per 1000 population and estimated trends ...
