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The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the nascent viral mRNA.
16 de nov. de 2018 · Here, we review the current knowledge on the process of IAV cap-snatching and suggest a requirement for RNAPII promoter-proximal pausing for efficient IAV mRNA transcription.
- Corey De Vlugt, Dorota Sikora, Martin Pelchat
- 10.3390/v10110641
- 2018
- Viruses. 2018 Nov; 10(11): 641.
5 de dic. de 2011 · However, they have evolved to steal caps from host mRNAs in order to prime their own viral replication, in a process known as cap snatching (Refs 105, 106, 107). Cap snatching involves three...
- Etienne Decroly, François Ferron, Julien Lescar, Julien Lescar, Bruno Canard
- 2012
19 de nov. de 2014 · Influenza virus polymerase uses a capped primer, derived by ‘cap-snatching’ from host pre-messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to generate the poly...
- Stefan Reich, Delphine Guilligay, Alexander Pflug, Hélène Malet, Imre Berger, Thibaut Crépin, Darren...
- 2014
8 de may. de 2023 · The MTr1 inhibitor TFTM prevents IAV and IBV cap-snatching and thus restricts viral replication. Host 5’cap0-mRNAs are matured to cap1 mRNAs by the cellular Cap-specific mRNA (nucleoside-2’-O...
Cap snatching is a transcription initiation process during which a nucleotide sequence between 10 and 20 nt in size is cleaved from the 5' end of host mRNAs by an endonuclease activity encompassed within the viral RdRp .
In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs. These heterologous sequences are acquired by a so-called cap-snatching mechanism.
