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  1. www.nature.com › articles › s41581/022/00601-zCellular senescence: the good, the bad and the unknown - Nature

    3 de ago. de 2022 · Cellular senescence regulates physiological and homeostatic processes, particularly during embryonic development and wound healing, but can also be a pathological process that contributes...

  2. www.ncbi.nlm.nih.gov › pmc › articlesCellular Senescence: Mechanisms and Therapeutic Potential

    25 de nov. de 2021 · Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both physiologically and pathologically.

    • 10.3390/biomedicines9121769
    • 2021/12
    • Biomedicines. 2021 Dec; 9(12): 1769.

  3. www.nature.com › articles › s41580/020/00314-wCellular senescence in ageing: from mechanisms to therapeutic ...

    16 de dic. de 2020 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...

    • Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d’Adda di Fagagna
    • 2021

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  5. www.ncbi.nlm.nih.gov › pmc › articlesMechanisms of Cellular Senescence: Cell Cycle Arrest and ...

    29 de mar. de 2021 · Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.

    • Ruchi Kumari, Parmjit Jat
    • 10.3389/fcell.2021.645593
    • 2021
    • Front Cell Dev Biol. 2021; 9: 645593.

  6. www.cell.com › cell › fulltextCellular Senescence: Defining a Path Forward: Cell

    Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly.

    • Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop...
    • 2019

  7. www.nature.com › articles › s42255/021/00483-8The metabolic roots of senescence: mechanisms and ... - Nature

    18 de oct. de 2021 · Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous biologically active molecules collectively...

  8. www.ncbi.nlm.nih.gov › pmc › articlesMechanisms and functions of cellular senescence - PMC

    2 de abr. de 2018 · Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different stresses. By imposing a growth arrest, senescence limits the replication of old or damaged cells.