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  1. es.wikipedia.org › wiki › CYP2E1CYP2E1 - Wikipedia, la enciclopedia libre

    Bioquímica. El CYP 2E1 representa un 5% de la actividad citocromo P450 del hígado. Está involucrado en el metabolismo de carcinógenos, es inhibido por disulfiram y la isoniazida al inicio de la terapia y es inducido por la isoniazida en el uso prolongado, el licor y la obesidad. 3 . Sustratos.

    • 1.14.14.1

  2. en.wikipedia.org › wiki › CYP2E1CYP2E1 - Wikipedia

    Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the ...

    • CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1

  3. scielo.isciii.es › scieloEstrés oxidativo hepatocitario y hepatopatía alcohólica

    Los niveles de CYP2E1 aparecen elevados en diversas condiciones fisiológicas y fisiopatológicas y tras el tratamiento alcohólico agudo y crónico. El CYP2E1 es también un eficaz generador de EOR, como el radical O 2 .- y el H 2 O 2 , y en presencia de catalizadores férricos produce potentes oxidantes, como el radical hidróxilo y el ...

  4. www.ncbi.nlm.nih.gov › pmc › articlesThe Role of CYP2E1 in the Drug Metabolism or Bioactivation in ...

    10 de ene. de 2017 · Animal models using genetic knockout of CYP2E1 and/or catalase indicate that CYP2E1 is responsible for ≈20% of ethanol metabolism in the brain. Catalase and CYP2E1 inhibitors diminish the accumulation of the ethanol derived acetaldehyde and acetate in brain homogenates.

    • W A García-Suástegui, L A Ramos-Chávez, M Rubio-Osornio, M Calvillo-Velasco, J A Atzin-Méndez, J Gue...
    • 10.1155/2017/4680732
    • 2017
    • Oxid Med Cell Longev. 2017; 2017: 4680732.

  5. www.genecards.org › cgi-bin › carddispCYP2E1 Gene - GeneCards | CP2E1 Protein | CP2E1 Antibody

    2 de abr. de 2024 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use Disorder . Among its related pathways are Metabolism of dichloroethylene by CYP450 and Oxidation by cytochrome P450 .

  6. www.ncbi.nlm.nih.gov › pmc › articlesCytochrome P450 2E1 and Its Roles in Disease - PMC

    1 de may. de 2020 · CYP2E1*1Cx2: CYP2E1.1: CYP2E1*1D: CYP2E1.1: 8 repeats in the 5’ flanking region: Increased activity after alcohol exposure and in obese subjects: CYP2E1*2: CYP2E1.2: 1132G>A: R76H: Reduced: CYP2E1*3: CYP2E1.3: 10023G>A: V389I: Normal: CYP2E1*4: CYP2E1.4: 4768G>A: V179I: Normal: CYP2E1*5A: CYP2E1.1: −1293G>C; −1053C>T (c1>c2 ...

  7. www.ncbi.nlm.nih.gov › pmc › articlesRole of Mitochondrial Cytochrome P450 2E1 in Healthy and ...

    15 de ene. de 2022 · Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death.

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