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Hace 2 días · Compared with standard hypoglycemic, intensive hypoglycemic reduced major kidney disease events (HR = 0.55, 95% CI 0.35–0.85, P = 0.007). and in all the T2DM patients, the number of major renal events in CC carriers was 37 (7.2%), while the number was 56 (6.7%) in CT/TT genotype patients, there were no significant differences between the two genotypes carriers (HR = 0.66, 95% CI 0.39–1.10 ...
Hace 3 días · The hypoglycemic effect of all compounds was evaluated by transgenic zebrafish model, and the structure–activity relationship was discussed. Hinokione (7, HO) has low toxicity and significant hypoglycemic effects on zebrafish, the mechanism is mainly by promoting the differentiation of zebrafish pancreatic endocrine precursor cells (PEP cells) into β cells, thereby promoting the ...
Hace 2 días · May 10, 2024. 0. An alarming lack of compliance with assessments to prevent ophthalmologic and neuropathic complications associated with diabetes has been detected in nine countries in Latin ...
Hace 4 días · Common causes of acute pancreatitis include concomitant medications (~500 drugs have been linked with pancreatitis, with at least 30 having a definite association), 21, 22 cholelithiasis, alcohol use, and hypertriglyceridemia. 20, 21, 27 In addition, the presence of T2D 28, 29 and/or established cardiovascular (CV) disease 30 increases the risk of acute pancreatitis compared with individuals ...
Hace 3 días · Currently, the primary drugs used in the clinical treatment of T2DM include biguanides, thiazolidinediones, and sulfonylureas (Zhang et al., 2019). Considering the limitations of the existing hypoglycemic drugs that need to be taken for long-term and have plenty of side effects, it is particularly urgent to continuously explore and develop practical, low-toxicity or non-toxic hypoglycemic drugs.
Hace 5 días · Dangerously lowered serum : glucose concentration; a toxic effect of high insulin concentrations and the secretagogue class of oral antidiabetic drugs Lactic acidosis Acidemia due to excess serum lactic acid; can result from excess production or decreased metabolism of lactic acid
Hace 4 días · The use of drugs to help regulate and control endocrine function is an important area of pharmacology. In one sense, hormones can be considered drugs that are manufactured by the patient's body. This situation presents an obvious opportunity to use exogenous chemicals to either mimic or attenuate the effects of specific hormones during endocrine dysfunction.
