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  1. 7 de oct. de 2021 · Epilepsy is a burdensome neurological disease known to increase mortality by up to 10 times among afflicted persons [1,2]. As secondary causes of epilepsy and co-existent neurological diseases become more prevalent, ageing populations are expected to face a rise in epilepsy-related mortality [ 3 ].

    • Overview
    • Signs and Symptoms
    • Rates of Disease
    • Causes
    • Treatment
    • Prevention
    • Social and Economic Impacts
    • Human Rights
    • Who Response

    Epilepsy is a chronic noncommunicable disease of the brain that affects around 50 million people worldwide. It is characterized by recurrent seizures, which are brief episodes of involuntary movement that may involve a part of the body (partial) or the entire body (generalized) and are sometimes accompanied by loss of consciousness and control of b...

    Characteristics of seizures vary and depend on where in the brain the disturbance first starts, and how far it spreads. Temporary symptoms occur, such as loss of awareness or consciousness, and disturbances of movement, sensation (including vision, hearing and taste), mood, or other cognitive functions. People with epilepsy tend to have more physic...

    Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. The estimated proportion of the general population with active epilepsy (i.e. continuing seizures or with the need for treatment) at a given time is between 4 and 10 per 1000 people. Globally, an estimated 5 million people are...

    Epilepsy is not contagious. Although many underlying disease mechanisms can lead to epilepsy, the cause of the disease is still unknown in about 50% of cases globally. The causes of epilepsy are divided into the following categories: structural, genetic, infectious, metabolic, immune and unknown. Examples include: 1. brain damage from prenatal or p...

    Seizures can be controlled. Up to 70% of people living with epilepsy could become seizure free with appropriate use of antiseizure medicines. Discontinuing antiseizure medicine can be considered after 2 years without seizures and should take into account relevant clinical, social and personal factors. A documented etiology of the seizure and an abn...

    An estimated 25% of epilepsy cases are potentially preventable. 1. Preventing head injury, for example by reducing falls, traffic accidents and sports injuries, is the most effective way to prevent post-traumatic epilepsy. 2. Adequate perinatal care can reduce new cases of epilepsy caused by birth injury. 3. The use of drugs and other methods to lo...

    Epilepsy accounts for more than 0.5% of the global burden of disease, a time-based measure that combines years of life lost due to premature mortality and time lived in less than full health. Epilepsy has significant economic implications in terms of health-care needs, premature death and lost work productivity. Out-of-pocket costs and productivity...

    People with epilepsy can experience reduced access to educational opportunities, a withholding of the opportunity to obtain a driving license, barriers to enter particular occupations, and reduced access to health and life insurance. In many countries legislation reflects centuries of misunderstanding about epilepsy, for example, laws which permit ...

    The first global report on epilepsy produced in 2019 by WHO and key partners, Epilepsy: A public health imperative, highlighted the available evidence on the burden of epilepsy and the public health response required at global, regional and national levels. The 75th WHA adopted the Intersectoral global action plan on epilepsy and other neurological ...

  2. Objectives People with epilepsy (PWE) have a higher mortality rate than the general population. Epilepsy-related deaths have increased despite all-cause mortality decreasing in the general population pre-COVID-19. We hypothesised that clinical and lifestyle factors may identify people more at risk.

    • Gabriella Wojewodka, Martin C Gulliford, Martin C Gulliford, Mark Ashworth, Mark P Richardson, Leone...
    • 2021
  3. 14 de jul. de 2023 · Premature mortality remains a major problem in patients with epilepsy globally. This chronic neurological condition poses a substantial burden for health systems, individuals, and their families. 4. , 5. , 6. , 7. Therefore, it is important for all health-care professionals to be familiar with this condition.

  4. 7 de abr. de 2023 · In this review, we aim to update current knowledge of the methodological aspects of research on mortality in epilepsy, causes of mortality, mortality in status epilepticus, as well as to set our sights on future directions in mortality research.

  5. 1 de feb. de 2015 · Results. The search strategy yielded 177 publications in MEDLINE and EMBASE, and 59 publications in LILACS; of which 18 met inclusion criteria for our overall review of epilepsy and mortality in Latin America. Most excluded studies did not report the mortality or lacked original data.