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13 de oct. de 2020 · En colaboración con Philip Siekevitz y George Palade, utilizando únicamente la técnica de fragmentación celular por centrifugación diferencial, realizó sus primeros descubrimientos; particularmente, encontró que la enzima glucosa-6-fosfatasa (G6P) es un marcador de retículo endoplásmico.
5 de abr. de 2010 · Then, in collaboration with George Palade, he demonstrated thecentral role of ribosomes in protein synthesis and, in particular, of membrane-boundribosomes in the synthesis of secretory proteins.
Keith Porter and George Palade, who at the Rockefeller Institute were making trailblazing discoveries with the electron microscope on the identification and structure of subcellular organelles, were among the many who appreciated Siekevitz’s development of an in vitro protein-synthesizing system.
- David D. Sabatini
- 2010
1 de nov. de 2002 · By 1956, the painstaking microscopic and biochemical characterization of microsomal fractions was published by Palade and Philip Siekevitz, who had joined the group in 1955.
- Alan M. Tartakoff
- 2002
Philip Siekevitz was integral to many aspects of the cell biology laboratory at Rockefeller University,guiding many students and postdoctoral fellows and collaborating with George Palade...
- Alan M. Tartakoff
- 2003
1 de jun. de 2011 · Philip Siekevitz and Palade first demonstrated that the “microsome fraction” consisted of fragments of endoplasmic reticulum (ER) [7,8]. Using detergent solubilization followed by centrifugation, Siekevitz and Palade subsequently found that microsome membranes consisted of ribonucleoprotein (RNP) particles [ 9 , 10 ].
Hace 1 día · In 1955, Palade recruited Phil Siekevitz to the Rockefeller Institute, with whom he undertook the task of characterizing the microsomal fraction, which they showed consisted of closed...
