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miRDB is an online database for miRNA target prediction and functional annotations. All the targets in miRDB were predicted by a bioinformatics tool, MirTarget, which was developed by analyzing thousands of miRNA-target interactions from high-throughput sequencing experiments.
24 de dic. de 2020 · MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs play gene-regulatory roles, producing remarkable changes in several physiological and pathological processes.
- Giulia Riolo, Silvia Cantara, Carlotta Marzocchi, Claudia Ricci
- 10.3390/mps4010001
- 2020
- Methods Protoc. 2021 Mar; 4(1): 1.
7 de jul. de 2021 · With miRTargetLink 2.0, we develop an all-in-one solution for human, mouse and rat miRNA networks. Users input in the unidirectional search mode either a single gene, gene set or gene pathway, alternatively a single miRNA, a set of miRNAs or an miRNA pathway.
- Fabian Kern, Ernesto Aparicio-Puerta, Yongping Li, Tobias Fehlmann, Tim Kehl, Viktoria Wagner, Kamal...
- 10.1093/nar/gkab297
- 2021
- 2021/07/07
In mammals, predictions are ranked based on the predicted efficacy of targeting as calculated using a biochemical model of miRNA-mediated repression, which was extended to all miRNA sequences using a convolutional neural network ( McGeary, Lin, et al., 2019 ).
- Performance Evaluation
- Comparing Mienturnet to Other Existing Tools
- Future Perspectives
To evaluate the performance of MIENTURNET, we tested it on simulated dataset designed to model the activity of a small set of miRNAs in a subset of samples (see “Implementation” section for further details). We analyzed the performance of MIENTURNET for different levels of miRNA activity by using Receiver Operator Characteristic (ROC) curve both fo...
As we stated above, the last few years have witnessed the increasing of web-based applications for supporting the identification of miRNA-target interactions that could be involved in various crucial cell processes or developmentally important cellular functions. Among them, the most used are miTEA , GSEA , miEAA , miRNet , and miRTargetLink . A co...
Currently, MIENTURNET supports the choice of six organisms (Table 1) for which both predicted and experimentally validated miRNA-target interactions were available. In future, we would like to include other organisms, like plants, when well-structured, easy downloadable and queryable databases will be available for both predicted and validated miRN...
- Valerio Licursi, Valerio Licursi, Federica Conte, Giulia Fiscon, Paola Paci
- 2019
Here, we describe recently updated features of miRDB, including 2.1 million predicted gene targets regulated by 6709 miRNAs. In addition to presenting precompiled prediction data, a new feature is the web server interface that allows submission of user-provided sequences for miRNA target prediction.
22 de nov. de 2012 · microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing.
