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Hace 1 día · We also used several computational methods (TargetScan, miRWalk, StarBase and miRcode) to help identify the potential targets of miR-22-3p and found that ETV1, a critical regulator in the progression of RCC , contained a putative binding site for miR-22-3p (Fig. 5D).
Hace 3 días · In this study, the potential targets of miRNA-200c-3p were searched in miRPathDB, Targetscan and PicTar. And there are 68 potential targets at the intersection of the three databases (Fig. 4 A). Then, bioinformatics and text mining performed by Coremine Medica, and found that among 68 potential targets, CRKL has the strongest correlation with EMT in TNBC (Fig. 4 B).
Hace 3 días · Our research involved a comprehensive analysis of miRPathDB, miRWalk, and Targetscan databases to identify the miRNAs associated with the 3′ UTR of human IL-2RG. The human microRNA (miRNA) molecules, hsa-miR-7-5p and hsa-miR-26b-5p, have been identified as potent suppressors of IL-2RG expression in CRC patients.
Hace 2 días · CircDGKZ promotes cardiomyocyte pyroptosis via miR-345-5p/TLR4/NF-κB. (A) Potential binding site predicted by TargetScan. (B) AC16 cells were transfected with wild-type or mutated TLR4 and then treated with miR-345-5p-NC or mimics. Luciferase activity was measured.
Hace 2 días · This database integrates information on miRNA regulation and signaling pathways and provides a collection of miRNA-target interactions and pathway annotations from various pathway databases. miRDB includes miRNA-target interactions from multiple sources, including TargetScan, miRTarBase, and DIANA-TarBase.
Hace 5 días · By intersecting the putative targets of miRNA-143/145 predicted using Targetscan and reduced 3’-UTR peaks (AGO2 IP), we identified 181 candidate target genes. KEGG pathway analysis revealed that the most highly enriched signalling pathway based on these 181 genes was the Hippo pathway (Fig. 4C).
Hace 2 días · We utilized the TargetScan predictive algorithm to identify putative Mirlet7 targets that are known to control the IL-17-mediated T cell response (Agarwal et al., 2015). This analysis revealed that the 3′UTR region of Rorc, encoding RORγt, contains an evolutionarily conserved and complementary motif for the Mirlet7 family .
