Su familia y amigos lo llamaban "Gabriel", pero en sus publicaciones ponía primero el nombre de Dante, debido a sus resonancias literarias. Era hermano de la poetisa Christina Rossetti y del crítico William Michael Rossetti, y fue uno de los fundadores de la Hermandad Prerrafaelita, junto con John Everett Millais y William Holman Hunt.
Later burials in the same grave are her mother-in-law Frances Rossetti (1886), Christina Georgina Rossetti (1895), and William Michael Rossetti (1919).  In August 1869, Rossetti authorized Charles Howell to disinter her coffin to retrieve a handwritten book of Rossetti's poems, which he had laid beside her head before burial.
William Michael Rossetti, his brother, wrote in 1895: "He was never confirmed, professed no religious faith, and practised no regular religious observances; but he had ... sufficient sympathy with the abstract ideas and the venerable forms of Christianity to go occasionally to an Anglican church — very occasionally, and only as the inclination ruled him."
Rossetti would rarely present his paintings in public. He also turned away from religious themes, choosing scenes from the literary works of William Shakespeare, Robert Browning, and Dante instead. In 1849, Rossetti met Elizabeth Siddall, one of his muses and models, whom he married in 1860.
Alexa Wilding (born Alice Wilding, c. 1847 – 25 April 1884) was one of the favourite models of the Pre-Raphaelite artist Dante Gabriel Rossetti, featuring in some of his finest paintings of the later 1860s and 1870s.
Christina Rossetti was born Christina Georgina Rossetti, on December 5, 1830, in Charlotte Street, London, England, to Gabriele Rossetti and Frances Polidori. She was the youngest of four children in the family with two brothers and a sister.